Oklo Inc. (NYSE: OKLO) has cleared a major regulatory hurdle after the U.S. Department of Energy approved its Documented Safety Analysis for the Groves Isotope Test Reactor in Texas.

The approval, granted under the DOE’s Reactor Pilot Program, moves the project into its final pre-startup review phase, bringing the advanced nuclear company closer to full operational authorization.

The Documented Safety Analysis provides a comprehensive technical assessment of potential hazards, required safety controls and operational procedures necessary to ensure safe reactor startup.

This latest approval follows the earlier clearance of the Preliminary Documented Safety Analysis, which established the project’s initial safety basis during design and construction stages.

With both approvals now secured, the Groves reactor can proceed through a readiness review and startup authorization, after which it will be permitted to receive and load nuclear fuel.

Following fuel loading, the facility will conduct startup testing and advance toward first criticality, the point at which the reactor sustains a controlled, self-sustaining nuclear chain reaction.

Oklo is targeting July 2026 for that first criticality milestone, marking a significant moment for the broader advanced nuclear industry.

The Groves project is notable as the first advanced reactor to receive DSA approval while operating on privately owned land and relying entirely on commercially sourced fuel, equipment and systems.

Construction and planned operations have been led by a private-sector team under DOE oversight, positioning Groves as a working model for the commercial reactors Oklo intends to build and operate at scale.

The Groves facility also serves a strategic role in expanding domestic production of critical isotopes used in cancer diagnosis and treatment, advanced manufacturing, scientific research, space exploration and national security.

Many of these isotopes are currently imported or produced at aging facilities, creating supply chain vulnerabilities for hospitals, research institutions and government agencies across the United States.

By launching operations through the pilot facility, Oklo aims to validate production processes, optimize reactor performance and establish reliable commercial-scale isotope output domestically.

The DOE approval follows Oklo’s recently announced acquisition of Creative Engineers Inc., a company specializing in alkali metal engineering for the nuclear industry, though financial terms were not disclosed.

The acquisition expands Oklo’s technical capabilities as it advances its next generation of nuclear technologies and works to solidify its position as a leading advanced nuclear developer.

GE Vernova Inc. (NYSE: GEV), a peer in the energy sector, carries a Zacks Rank of 2 (Buy), with its 2026 earnings consensus estimate pointing to 73.2% year-over-year growth.

NextEra Energy, Inc. (NYSE: NEE), a Juno Beach, FL-based public utility holding company, also holds a Zacks Rank of 2 (Buy), with 2026 earnings consensus growth projected at 8.1% year-over-year.

Atlanta-based The Southern Company (NYSE: SO), one of the largest utilities in the United States, carries the same Zacks Rank of 2 (Buy), with 2026 earnings consensus growth estimated at 6.5% year-over-year.

Oklo itself currently holds a Zacks Rank of 3 (Hold) as it approaches what could be a defining operational milestone in the advanced nuclear sector.